Fda also intends to actively monitor and.

Mature women taking osteoporosis drugs known as bisphosphonates, at least five years, is likely to sustain atypical fractures of the femur, compared with women who take medication for a shorter period of study. The study showed that taking such drugs as Actonel (ryzedronat), Didrocal (etidronat) or Fosamax (alendronate) for five or more years was associated with 2. 7 times higher risk of hospitalization for unusual fractures of the femur, compared with shorter drug use. In other words, the absolute risk of atypical femoral fracture was one in 1000 among women taking bone building drug for five years or more, said lead author Laura Park-Villa, and the results of pharmaceutical research fellow of St. Michael's Hospital in Toronto. "They differ from typical fracture of the hip joint, as the typical hip fracture would take place at the top of the femur or thigh bone near the hip joint," she said. "And these hip fractures we studied is below from the hip, closer to mid-thigh."

The results included in the online issue on Wednesday in the Journal of the American Medical Association, should be warning by Health Canada in October about a possible link between prolonged use of drugs and unusual femur fractures. Suspects link also prompted the U.S. Food and Drug Administration to amend the labeling of drugs. Signs of a possible hip fracture include new or unusual pain in the groin, thigh or hip. In patients taking bisphosphonates that have this type of pain is recommended to consult a medical professional. "Even if we found a small increased risk of hip fractures, I think, to help put this in perspective, it is also important to note that the absolute risk of fractures was low," said Willie Park. Weight bearing exercise can help increase bone density to prevent osteoporosis, but bisphosphonates drugs for the treatment of this disease can slightly increase the risk of hip fractures. (Donna McWilliam / Associated Press) "osteoporosis fractures of the hip and spine and wrist more often than that," she said, noting that research shows women who take drugs for five-plus years has been to reduce the risk of such " typical 'fractures. "Thus, women with osteoporosis who are at high risk of osteoporosis, fractures that occur more frequently than, those thighs, they should not stop taking their treatment because on average in favor of continuing outweigh the risk."

A number of factors put men and women at high lasix online no prescription risk of fractures associated with brittle bones, says Osteoporosis Canada. Among them:

being aged 65 and older. The presence of family history of osteoporosis. Long-term use of certain medications such as prednisone. Some medical conditions that prevent the absorption of nutrients. Low calcium intake. Smoking. Excessive consumption of alcohol. However, women with low risk of fractures associated with osteoporosis, bisphosphonates have been proposed to speak to their doctors that they should continue the drug, Villa Park is recommended. "There's less to it was made for women on these drugs to begin with, as a whole for the benefit of these drugs for women who are at high risk."

For the study, researchers analyzed hospital and prescription records for more than 205,000 postmenopausal women in Ontario who were taking oral bisphosphonates for the period from April 2002 to March 2008. Participants were aged 68 or over and watched for 31 March 2009. The study, 716 were hospitalized with atypical femur fracture. "These new results from Ontario are consistent with what we know," said Dr. Angela Cheung, vice-chairman of the Scientific Advisory Board of Osteoporosis Canada. "There are many things that we do not understand about these fractures," said Chung, a specialist in internal medicine at the University Health Network in Toronto, who was not involved in the study. "What we know, the type of fracture is more like a stress fracture, and we try to understand who is most likely to be."

To this end, she leads a group that is under construction throughout the Canadian registry of cases. FDA also intends to actively monitor U.S. cases of bisphosphonates-induced atypical fractures. "It's rare, but we must pay attention," said Chung. Canadians who have experienced atypical fractures of the femur can join the registry by email osteoporosis (in) UHN. at. ca or call 416-340-4843. .